Life Sciences
San Francisco, CA
Achaogen, Inc.
NASDAQ: AKAO
Therapeutics for combating the increasing bacterial resistance to antibiotics
Seattle, WA
Acylin Therapeutics Corp.
Small molecule drug development
Acquired by Global Publicly-traded Biopharmaceutical Company
Exton, PA
Adolor Corporation
NASDAQ: ADLR
Analgesic pharmaceuticals
Acquired by Cubist Pharmaceuticals, Inc.
NASDAQ: CBST
Cambridge, MA
Agios Pharmaceuticals, Inc.
NASDAQ: AGIO
Cancer therapies addressing cellular metabolism
Seattle, WA
Allozyne, Inc.
Enhanced potency, tolerability and pharmacology of protein based therapeutics
Concord, MA
Alnylam Holdings, Inc.
NASDAQ: ALNY
RNA interference-based pharmaceuticals
Boulder, CO
Array BioPharma, Inc.
NASDAQ: ARRY
Chemical intermediate sales and chemistry outsourcing
Mountain View, CA
Aviron, Inc.
NASDAQ: AVIR
Live attenuated vaccines including FluMist
Acquired by MedImmune, Inc.
NASDAQ: MEDI
Hampton, NJ
Bellerophon Therapeutics
NASDAQ: BLPH
Therapies for cardiac treatment
Cambridge, MA
BIND Therapeutics, Inc.
NASDAQ: BIND
Biopharmaceutical firm developing therapeutics targeted nanoparticles
San Diego, CA
Blackthorn Therapeutics, Inc.
Target medicines for neurodevelopmental disorders
Cambridge, MA
Bluebird Bio, Inc.
NASDAQ:BLUE
Gene therapies for childhood cerebral adrenoleukodystrophy (CCALD) and beta-thalassemia/sickle cell anemia
Mountain View, CA
Caliper Life Sciences, Inc.
NASDAQ: CALP
Pioneer in microfluidics ("lab on a chip") for research instrumentation and drug screening

Acquired by PerkinElmer, Inc.
NYSE: PKI
Dublin, Ireland
Carrick Therapeutics, Ltd.
First-in-class cancer treatments that target driver mechanisms of the most aggressive forms of cancer
Boston, MA
Chiasma Corp.
NASDAQ: CHMA
New drug development technology enabling drugs to be switched from injectable to oral, creating new indications or improved labels
Seattle, WA
Codiak Biosciences, Inc.
Exosome technology for cancer diagnosis/therapy
San Francisco, CA
Denali Therapeutics, Inc.
Neurodegenerative disease therapeutics
San Francisco, CA
Encoded Genomics, Inc.
Genomic sequencing for drug development
Cambridge, MA
Ensemble Therapeutics, Inc.
Chemical synthesis platform using DNA-programmed chemistry to develop synthetic macrocycle drugs called Ensemblins™
Seattle, WA
Faraday Pharmaceuticals, Inc.
Developing therapies to treat ischemia-reperfusion injury
La Jolla, CA
Fate Therapeutics, Inc.
NASDAQ: FATE
Adult stem cell biology
Gaithersburg, MD
GenVec, Inc.
NASDAQ: GNVC
Gene therapy for cardiovascular disease and cancer
San Francisco, CA
GRAIL, Inc.
Liquid biopsy using ultra-deep sequencing for cancer detection
Boston, MA
Homology Medicines, Inc.
Gene editing using “molecular scissors” to repair gene defects
Shanghai, China
Hua Medicine, Inc.
Sourcing drug discovery technology in U.S. and China
LaJolla, CA
IDUN Pharmaceuticals, Inc.
Discovery of small molecule drugs that interfere with apoptosis
Acquired by Pfizer
NYSE: PFE
Hampton, NJ
Ikaria, Inc.
Biotherapeutics to address unmet medical needs of critically ill patients
Acquired by Madison Dearborn Partners
Acquired by Mallinckrodt
NYSE: MNK
San Diego, CA
Illumina, Inc.
NASDAQ: ILMN
Fiber optic arrays for use in genomics
Seattle, WA
New York, NY
ISB Accelerator Corp.
Building the next generation of biotech companies by providing resources critical to the achievement of scientific proof-of-concept
La Jolla, CA & Cambridge, MA
Kura Oncology, Inc.
NASDAQ: KURA
Therapeutics based on cancer genetics
Woodland Hills, CA
Kythera Biopharmaceuticals, Inc.
NASDAQ: KYTH
Aesthetic and dermatologic prescriptive therapies
Acquired by Allergan
NYSE: AGN
Seattle, WA
Juno Therapeutics, Inc.
NASDAQ: JUNO
Curative cancer immunotherapy treatments
New York, NY
Lodo Therapeutics Corp.
Therapeutics based on meta-genomics for emerging bacteria and drug-resistant bacteria
Ann Arbor, MI
Lycera Corp.
Mitochondrial biology platform for discovery of small molecules related to diseases/conditions with abnormal cell activity
San Diego, CA
Metacrine, Inc.
Metabolic disease therapeutics
Seattle, WA
Nemean Pharma Corp.
Therapeutics targeting AML and CML
San Carlos, CA
NeurogesX, Inc.
NASDAQ: NGSX
Pharmaceuticals for intractable pain relief
Acquired by Acorda Therapeutics, Inc.
NASDAQ: ACOR
Seattle, WA
Nura, Inc.
Treatments for neurodegenerative diseases and behavioral disorders
Acquired by Omeros Corp.
NASDAQ: OMER
Seattle, WA
Omeros Corp.
NASDAQ: OMER
Pharmaco Surgery™ drug platform to reduce trauma from surgical and medical procedures
Cambridge, MA
Permeon Biologics, Inc.
Intracellular biotherapeutics platform to enhance drug delivery
New York, NY
Petra Pharma Corp.
Small molecule therapeutics for cancer and metabolic diseases
Seattle, WA
PhaseRx, Inc.
NASDAQ: PZRX
siRNA drug delivery technology
Lexington, MA
Pulmatrix, Inc.
NASDAQ: PULM
Inhaled therapeutics for respiratory disease and infections
San Diego, CA
Receptos, Inc.
NASDAQ: RCPT
Biopharmaceutical company developing therapeutic candidates for the treatment of immune and metabolic diseases
Acquired by Celgene
NASDAQ: CELG
Cambridge, MA
Sage Therapeutics, Inc.
NASDAQ: SAGE
Therapeutics to treat severe nerological conditions such as Fragile X Syndrome and traumatic brain injury
Cambridge, MA
Scholar Rock, LLC.
Novel biologics that selectively target growth factors in the disease microenvironment
Cambridge, MA
Semma Therapeutics, Inc.
Therapeutics for Type I Diabetes
Watertown, MA
Syros Pharmaceuticals, Inc.
Mapping gene regulatory circuits and modulating gene expression factors
Seattle, WA
Theraclone Sciences, Inc.
Human monoclonal antibody platform with multiple therapeutic product candidates
Seattle, WA
Trubion Pharmaceuticals, Inc.
NASDAQ: TRBN
Alternate antibody scaffold platform company
Acquired by Emergent BioSolutions, Inc.
NYSE: EBS
San Francisco, CA
Unity Biotechnology, Inc.
Therapeutics designed to prevent, halt or reverse numerous diseases of aging
Cambridge, MA
Gatineau, Quebec, Canada
VBI Vaccines, Inc.
NASDAQ: VBIV
Vaccine technology platform company enabling the development of thermostable and oral vaccines
Seattle, WA
VentiRx Pharmaceuticals, Inc.
Developing immunoregulatory therapies based on innate immunity
Seattle, WA
VLST, Inc.
Virology-based platform for improved identification and validation of cell targets for therapeutic drug development
Seattle, WA
Xcyte Therapies, Inc.
NASDAQ: XCYT
Immune therapy for cancer
Merged with Cyclacel Group plc
NASDAQ: CYCC
Palo Alto, CA
XenoPort, Inc.
NASDAQ: XNPT
Enhanced drug delivery